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Spokehead Inner sheath Radial spoke 100nm
Doublet microtubule Interaction between cargo and motor proteins is often
indirect Dynactin is an “adaptor” complex between dynein and
its cargo; adaptors also exist for kinesins Cargo specificity
--Multiple motor proteins can bind to a given cargo
--Each kinesin/dynein transports specific cargoes
--Different motor proteins can interact with different adaptors and different
cargo Transport can be regulated by signals: Movement of pigmented
granules in a cell Movement of pigmented granules in a cell Intracellular transport,
and ER growth require
motor proteins and
microtubules Mitochondria moving along an axon in a live
zebrafish embryo Mitochondria moving along an axon in a live
zebrafish embryo Microtubules assemble from organizing centers
MTOC; Ab against centrosomal protein EM; centrosome (colored red) has two
centrioles. PC is pericentriolar material. Microtubules are responsible...
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This note was uploaded on 02/23/2014 for the course MCDB 165A taught by Professor Iruela-arispe during the Winter '08 term at UCLA.
- Winter '08