Lecture 8--intracellular transport

Singlets plasma membrane outer dynein arm central

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Unformatted text preview: air of single microtubules Spokehead Inner sheath Radial spoke 100nm A tubule B tubule Doublet microtubule Interaction between cargo and motor proteins is often indirect Dynactin is an “adaptor” complex between dynein and its cargo; adaptors also exist for kinesins Cargo specificity --Multiple motor proteins can bind to a given cargo --Each kinesin/dynein transports specific cargoes --Different motor proteins can interact with different adaptors and different cargo Transport can be regulated by signals: Movement of pigmented granules in a cell Movement of pigmented granules in a cell Intracellular transport, organelle positioning, and ER growth require motor proteins and microtubules Mitochondria moving along an axon in a live zebrafish embryo Mitochondria moving along an axon in a live zebrafish embryo Microtubules assemble from organizing centers MTOC; Ab against centrosomal protein EM; centrosome (colored red) has two centrioles. PC is pericentriolar material. Microtubules are responsible...
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