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2.08.06 L49

2.08.06 L49 - Lecture 49 Genes to Proteins II Transcription...

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May 12, 2009 Lecture 49: Genes to Proteins II  RNA Single Stranded Self folds in a very precise manner Ribose (not deo xyribose) sugar Uracil, not thiamine Like DNA, adds to 3’ end The Genetic Code: How many nucleotides needed? o 2 gives only 16 combinations (to few) o 3 gives 64 combinations (right by parsimony) o 4 gives 256 combinations (too many) Evidence for Triplet Code Genetic crosses with one or two nucleotides added into DNA: hig genetic effet Add 3 nucleotides: small effect. Tus probably, triplet code Nirenberg cracked genetic code using synthetis mRNA. The code has redundancy: more than one nucleotide for each amino acis. A “Degereate CodE” Exampls: UUU, CCA, UAG, etc. The Breakdown of the Genetic Code:
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2.08.06 L49 - Lecture 49 Genes to Proteins II Transcription...

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