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Engl j med 2009 3601500 1525 bat ac9vity monitored by

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Unformatted text preview: 1) H+ BAT may be important in protec9ng against obesity N.Engl J Med 2009; 360:1500- 1525 BAT ac9vity monitored by PET- CT scans Thermoneutral condi9ons Cold exposure 3 11/14/13 Temperature decrease ac9vate brown fat (thermogenin) and hormones which increase TAG breakdown H+ Pi ADP ATP H+ Pi ADP ATP HEAT H+ FADH2 NADH FAD+ O 2 NAD+ H2O uncoupling protein 1 (UCP-1) H+ 4 11/14/13 Lipids are Func9onally Diverse Biomolecules Passive: - High Energy Storage Molecules (TAG) - Insula9on (brown fat) Ac+ve: - Biological Membranes (PLs, cholesterol) - Modula9on of Signal Transduc9on (Eicosanoids and Prostaglandins) Carboxylic acid Faay Acids the Simple Lipids Hydrocarbon tail, (Acyl chain) Usually, an even number of carbons 4- 36, but 16 and 18 carbon faay acids most common 16:0 18:0 5 11/14/13 Common Animal Saturated Faay Acids Common...
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