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C349_Ex5_L3 - Poster Presentations(in Sci 243/245 Wed Dec...

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12/10/13 1 Poster “Presentations” (in Sci 243/245) Wed. Dec- 11-11:15-12:30 Thurs. Dec-12-12:45-1:45 Fri. Dec 13-11:30-12:30 + H 3 N CH COO - CH 2 CH 2 CH 2 NH 2 + C O NH 2 This amino acid is…. A. Arginine B. Lysine C. Citrulline D. Ornithine E. Not sure
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12/10/13 2 The first step in the urea cycle (which occurs in the matrix) is to synthesize citrulline from ornithine & carbonyl phosphate + H 3 N CH COO - CH 2 CH 2 CH 2 NH 3 + O PO 3 -2 C NH 2 O Pi + H 3 N CH COO - CH 2 CH 2 CH 2 NH 2 + C O NH 2 Ornithine transcarbonylase In our discussion about urea and the urea cycle we want to explore the following questions.. 1. One function of the urea cycle is to make urea, what is another function of this cycle? 2. What amino acids are involved in the urea cycle? If any? 3. What is the origin of the NH 2 groups in urea? What about the carbon? NH 2 C O H 2 N 4. Is there a connection of the urea cycle to the citric acid cycle? What is it?
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12/10/13 3 + H 3 N CH C CH 2 O - O CH 2 CH 2 NH 3 + Pi ATP AMP COO - CH CH COO - H 2 O NH 2 CH H 2 C COO - - OOC OPO 3 -2 C NH 2 O amino acid keto acid Matrix The urea cycle We will go over this at the board in class Argininosuccinate Fumarate Oxaloacetate A. B. D. C. E. Glutamate Can you complete the bicycle below?
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12/10/13 4 Connection of the urea cycle to gluconeogensis Arginine Ornithine Arginosuccinate Citrulline Carbonyl phosphate Urea Fumarate Aspartate Malate Oxaloacetate Phosphoenolpyruvate Glucose Arginine
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