Allosteric interacons catabolism anabolism 2

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Unformatted text preview: tabolism Anabolism 2. Compartmenta.on 3. Covalent Modifica.ons 4. Enzyme concentra.ons 2 12/12/13 Control points 1.  Glycolysis- PFK –hi [ATP] & [citrate] inhibits / F2,6 bis- P ac.vates pyruvate kinase- hi [ATP] inhibits 2.  PDH- inhibited by hi [NADH] & [acetyl CoA] 3. Citric Acid Cycle- isocitrate & ketoglutarate dehydrogenase- hi [NADH] inhibits 4.  Electron Transport- oxida.on of NADH- hi [ATP] inhibits 5.  Pentose Pathway- controlled by [NADP+] 6.  Gluconeogenesis- F1,6- bisphosphatase- hi F2,6 bis- P inhibits/ [citrate] ac.vates 7.  Glycogen Synthesis/degrada.on- controlled reciprocally by hormone cascade 8.  Fa[y acid Synthesis/degrada.on- hi [FA] inhibit ACC, whereas hi [citrate] ac.vates hi [malonyl CoA] inhibits acyl transferase Liver Fed State Glucose Acetyl CoA cholesterol Fasted State Glycogen Glycogen...
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