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Unformatted text preview: st have an
affected father and
either an affected or
carrier mother. Example of an X-linked Recessive Trait
• Hemophilia A: people bleed excessively, so that even small cuts
and bruises can be life-threatening. • Mechanism: • Absence of a protein necessary for blood clotting, factor VIII.
• Can be controlled by administering concentrated doses of
factor VIII. • Inheritance:
• The gene encoding factor VIII is located on the X
chromosome. No genetics course would be complete
tended to die
royal family X-linked (Sex-linked) Dominant Traits
• Affected males: all
• Affected mothers
have ½ affected sons
and daughters and ½
normal sons and
• Trait does not skip
generations. Example of an
X-Linked (Sex-linked) Dominant Trait
• Hypophosphatemia: familial vitamin-D-resistant rickets. • Bone deformities, stiff spines and joints, bowed legs, and
mild growth deﬁciencies. • Resistant to treatmen...
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