Unformatted text preview: aits Pedigrees: Common Symbols
(Yes, you need to know these) Pedigrees: Common Symbols
(Yes, you need to know these) Example:
Pedigree of Waardenburg Syndrome Proband, the
initiated Waardenburg syndrome is an autosomal dominant
type of deafness that may be accompanied by fair skin,
a white forelock, and visual problems. Pedigree Analysis: Why?
• Limited number of progeny; thus Mendelian ratios impossible to
• Analysis of pedigrees requires recognizing patterns associated
with different modes of inheritance Autosomal Recessive Traits
CARRY RECESS. WOULD
HAVE 3:1 • Normal parents have
• Equal number of males
and females affected.
• ~1/4 of the offspring of
two carriers are affected. Autosomal Recessive Traits • Normal children with
affected siblings: 2/3
chance of being a carrier.
• Consanguineous matings
are sometimes involved. Example of an Autosomal Recessive Trait • Tay-Sachs Disease: • Degenerative nervous...
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