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Hdac histone deacetylases hdacs take acetyl off hdacs

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Unformatted text preview: e DNA • Eukaryotic transcripts undergo extensive processing to form a mature mRNA molecule Chromatin Remodeling Chromatin structure can be modified to allow more access to DNA, or to allow less Histone acetylation: acetyltransferases destabilize nucleosome structure by making histones more negatively charged Allows more transcription What effects should histone deacetylases have? Hdac Histone deacetylases (HDACs) take acetyl off HDACs should result in more tightlywound DNA = less transcription Eukaryotic Transcription: How it differs • Chromatin must be remodeled to allow transcription factors access to the DNA • Eukaryotic transcripts undergo extensive processing to form a mature mRNA molecule • Which brings us to Chapter 14 Lecture 11: Transcription, RNA Molecules and Processing, Translation and the Code July 24, 2013 • RNA Molecules and RNA Processing • Gene Organization • Genes and proteins are colinear • Eukaryotic genes are interrupted • Types of Introns • Eukaryotic transcripts are extensively modified • mRNA structure • Capping • Tailing • Splicing • Alternative Splicing • Editing • tRNA structure and processing • rRNA structure and processing • Small RNA molecules and their functions What is a gene? In 1953, the structure of DNA was published It was accepted that DNA was the hereditary material So, DNA somehow contains genes. In 1958, Francis Crick proposed the “sequence hypothesis”: A gene is a linear sequence of nucleotides, and each gene encodes a single protein What is a gene? To this point, genes were considered to be indivisible units Seymour Benzer showed that it was possible for recombination to occur within a gene What does this imply about gene structure? Genes and Proteins are Colinear A continuous DNA sequence codes for a continuous sequence of amino acids This proved to be true for prokaryotic genes Eukaryotic genes are more complicated Eukaryotic Genes Colinearity predicts that the number of nucleotides in a gene should be proportional to the number of amino acids in a protein This is true...
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