Fix mistakes from first missense suppressor mutations

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Unformatted text preview: here to make up for damage • A second suppressor mutation at a different site may restore the interaction and folding pattern. fix mistakes from first missense Suppressor mutations offisite in diff gene • Intergenic suppressor mutations occur in a gene other than the one with the original mutation. • May change the way an mRNA is translated (next slide) • May work through gene interactions. • If an original mutation interferes with binding between two proteins, a second mutation may restore the binding. • If an original mutation causes an overactive protein that signals constantly, a second mutation that alters a protein downstream in the pathway can suppress the first mutation One type of intergenic suppression: nonsense suppression Wild-type sequence Base substitution Base substitution at a second site add trna which recognizes mutation and function my be restored nonsense Text anino acid is changed Mutations are caused by a number of different factors • Mutations result from internal and external factors. • Those that are a result of natural changes in DNA structure are termed spontaneous mutations. • Spontaneous errors can arise in replication. dna polym can mess up • Mutations can arise from spontaneous chemical changes in DNA. Text Mutations are caused by a number of different factors • Mutations result from internal and external factors. • Those that result from changes caused by environmental chemicals or radiation are induced mutations. • Chemically induced mutations • Radiation-induced mutations Mispairings that occur through “wobble” comprise many replication errors re...
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This document was uploaded on 02/25/2014.

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