F13 17 Viruses and Prions

Makes a dbl stranded intermediate if negative

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Unformatted text preview: ME. MAKES A DBL STRANDED INTERMEDIATE. IF NEGATIVE TEMPLATE STRAND IS THE MESSAGE FOR PROTEIN HIV 29:49 DNA FROM RNA TEMP. CAPSID T -ENVELOPED VIRUS, HAS HOST CELL MEMBRANE WITH SOME ADHESINS. -IT HAS ENZYME REVERSE TRANSCRIPTASE, BUT NOT A METABOLIC ENZYME. REVERSE TRANSCRIPTASE ALLOWS DNA TO BE MADE FROM RNA TEMPLATE. -HAS 2 PROTEINS GP41 AND GP 120 -GP120 MAKES CONTACT WITH HOST RECEPTOR CD4. CCR5 THEN INTERACTS WITH THIS COMPLEX AND GP41 WILL MEDIATE THIS COMPLEX OF VIRAL ENVELOPE AND HOST CELL MEMBRANE. VIRAL CAPSID WILL THEN ENTER THE CELL AND DEGENERATE THE CELL. CD4 IS ONLY FOUND IN HUMAN LYMPHOCYTES. “PREVALENCE” 1984 1990 2004 NOT AS PREVALENT, DOES NOT PERSIST 12/2 40:02 Influenza virus GOAL OF VIRUS: KEEP HOST ALIVE, LONGER HOST IS ALIVE AND THE LONGER THE VIRUS CAN BE INFECTIVE, THEN THE MORE REPLICATION THAT CAN BE ACHIEVED. HOT VIRUS: EX MARBURG VIRUS; THEY KILL THE HOST CELL SO FAST THAT THEY ARE SELF LIMITING, KILL HOST IN 4-5DAYS AND RESULTS IN LOWERED PROPAGATION RATE STRATEGY: HOP BETWEEN SPECIES, RNA VIRUS, DOES NOT HAVE TYPICAL CAPSID, GENOME IS IN SEGMENTS. INFLUENZA: CAN HAVE SEVERE CASE, VIRUS WILL HOP DIFFERENT SPECIES, EVERY ONCE IN A WHILE, IT INVADES THE HUMAN POPULATION/ -ENVELOPED VIRUS -HAVE TYPICAL CASPID -SEGMENTED GENOME. EPIDEMIC 43:48 MAP NOT VERY ACCURATE, IT’S LIKELY THAT VIRUS STARTED IN THE U.S. AND IN KANSAS, GOT INVOLVED WITH WAR CAMPS, INFECTED SOLDIERS THEN CAME BAC AND INFECTED VRUS. MUST SYTNTHSIZE PROTEIN AND ENVELOPE, BECAUSE T’S SEGEMENTAED,IT SEGMENT CAN RECOMINE AND THEN REINCORPORATE THE PROPERTIES OF EACH GENOME (EX AVIAN STRAIN CAN NOW INFECT HUMANS) THIS IS DUE TO A RECOMBINATION EVENT WHICH IS HARMFUL TO HUMAN POPULATION END 12/2 Viral cultivation/detection: • Phage: Bacterial lawn/ plaques (quantitate/clone) • Animal/plant viruses: – Living tissue • Tissue culture • Cytopathic effects (CPE) – Whole organism/embryonated eggs 12/4 CYTOKINE STORM...
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This document was uploaded on 02/25/2014 for the course MICROBIOLO 101 at San Jose State.

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