10.24.05 - Orange = structure Blue = function cell...

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October 24, 2005 cell signaling II Signal Reception Membrane Receptors (embedded) o G-Protein coupled receptors (GPCR) o Ligand gated ion channels o Receptor tyrosine kinases. Cytoplasmic Receptors (inside) GPCR 7 alpha helixes  Signal binds to first and transmits signal (not the actual signal) G-protein (has a bonding site for GDP) inside the membrane Signal molecule bines to GPCR site causind the G-Protein to lose its GDP and  gain a GTP. Once GTP binds to G-Protein, protein splits in half and one half goes to an  inactivated enzyme G-Protein activates enzyme and signal pops off receptor. Real Life examples: Thyroid gland, epenepherine in heart in muscle. Very popular in animals, few in plants, none in fungi. Ligand-Gated Ion Channels Signal molecule (ligand) bonds to reception site on gate molecule
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