Lecture10_Unit3&4-Nucleic acids+Transcription-student

B c d e n terminus c terminus 5 3 phosphate end

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Unformatted text preview: ers, residues and polymers, polarity, extensibility, “condensaRon” reacRons Link organic chemistry of the macromolecules (nucleic acids and proteins) to the structure.   recognize how non- covalent interacRons, including hydrophobic/hydrophilic interacRons, drive the three- dimensional structure of macromolecules.   informaRonal vs. non- informaRonal processes for determinaRon of the sequence of residues in a heteropolymer.           Fig. 5- 2: Icon/LEGO view of DNA structure Q1. This building block of DNA is called A.  NucleoRde B.  Amino acid C.  Nucleoside D.  Ribonucleic acid E.  Deoxyribonucleic acid Figure 5- 2 Nucleotides Are the Subunits of DNA and RNA Nucleoside = base + sugar Nucleotide = base + sugar + phosphate Bases = purines (A,G) & pyrimidines (C,T,U) Panel 2- 6 Bifunctionality/Polarity of Nucleic acids is described in terms of: A .  B.  C.  D.  E.  N- terminus & C- terminus 5’ & 3’ Phosphate end & Sugar end Phosphate end & Ribose end α-(1→4) linkage or β-(1→4) linkage ECB Fig 6- 10 Directionality/polarity of Nucleic acids is described as: 5’ and 3’ ends Why? Note numbering on deoxyribose ring.  Consistent 5’ 3’ polarity throughout the molecule; all nucleoRdes are oriented in the same direcRon.  3’ OH always available for addiRon of new residue. What is the direcRon of DNA synthesis? Or see Flash animaRon on Vista Fig 6- 10 Problem 3.6 in Topic 2: Nucleic acids A B Here are...
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