Lecture14-Unit5-ER&vesicles-student

Snares are involved in the mediakon of protein

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Unformatted text preview: pathway Vesicle must take the correct cargo to correct target Two important consideraKons:   selecKon and concentraKon of the vesicle content (as part of the vesicle formaKon process), and   targeKng of the vesicle to the correct desKnaKon membrane SelecKon and ConcentraKon of vesicle contents dependent on the vesicle coats COP coat Clathrin coat Fig. 15- 19: Clathrin coated vesicles transport selected cargo 3. coat is shed 2. pinching off 1. budding See also Vista anima&on on vesicle forma&on Figure 15- 20 Essen&al Cell Biology (© Garland Science 2010) 4. naked vesicle ready to fuse Different types of coat proteins used in vesicle formaKon in different parts of the endomembrane system Figure 13- 5 Molecular Biology of the Cell (© Garland Science 2008) Molecular model of clathrin coat (Figure 13-7c, d MBoC) clathrin Figure 15-19b ECB Fig. 15- 20: What do you predict would happen if the dynamin protein was defecKve? A.  B.  C.  D.  E.  Vesicles don’t uncoat Too many vesicles bud off Cargo doesn’t concentrate Vesic...
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