Lecture17-Unit5-Endocytosis-student

All of the above inclusion cell i cell disease in

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Unformatted text preview: ngle gene defect is found in the enzyme which adds phosphate to mannose-6-phosphate oligosaccharides in Golgi. 1. Why are the lysosomal enzymes in the blood? A.  B.  C.  D.  E.  Undigested material accumulates and leaks. Lysosomal enzymes lack oligosaccharides. Lysosomal enzymes are secreted by accident. The mannose-6-phosphate receptor is defective. All of the above Inclusion-cell (I-cell) disease In patients with I-cell disease, fibroblasts do not digest material in their lysosomes, undigested material accumulates as “inclusions”. •  The lysosomal enzymes are found in the patients blood. •  A single gene defect is found in the enzyme which adds phosphate to mannose-6-phosphate oligosaccharides in Golgi. 2. Which of the following is the primary defect? (i.e. the direct result of the mutation?) A.  Undigested material accumulate...
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This document was uploaded on 02/26/2014 for the course BIOL 200 at UBC.

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