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Lecture17-Unit5-Endocytosis-student

Lecture17-Unit5-Endocytosis-student - Lysosomes Figure 15...

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Lysosome’in’the’liver’ cell’of’a’rat.’ Lysosomes’ Figure’15-35’(15-34’2 nd ’edi>on)’
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Lysosomes’ Figure’15-35’(15-34’2 nd ’edi>on)’ Vacuoles’in’plant’cells’also’ func>on’as’lysosomes’
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Clicker Q: Put’the’events’in’this’list’in’the’correct’order’ 1. Vesicles’fuse’with’late’ endosomes’with’a’lower’pH’environment’-’where’ the’cargo’dissociates’from’the’receptor’and’the’receptor’is’recycled.’ 2. Lysosomal’proteins’have’a’core’sugar’transferred’to’them’from’ dolichol.’ This’is’trimmed’and’processed’so’that’it’consists’primarily’of’mannose’ sugars.’ 3. An’enzyme’transfers’a’phosphate’to’the’mannose’sugars’so’that’they’ become’mannose-6-P.’ 4. Phosphate’is’removed’from’the’ lysosomal’protein’by’another’enzyme’ (phosphatase)’before’the’protein’can’become’func>onal.’ 5. The’receptors’for’M6P’bind’to’all’the’proteins’containing’M6P’and’gather’ them’together’into’a’vesicle’–’with’ clathrin’coat.’ A. 2,’5,’3,’4,’1’ B. 2,’3,’5,’1,’4’ C. 4,’1,’5,’3,’2’ D. 5,’4,’3,’2,’1’
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Inclusion-cell (I-cell) disease In patients with I-cell disease, fibroblasts do not digest material in their lysosomes, undigested material accumulates as inclusions . The lysosomal enzymes are found in the patients blood. A single gene defect is found in the enzyme which adds phosphate to mannose-6-phosphate oligosaccharides in Golgi . 1. Why are the lysosomal enzymes in the blood? A. Undigested material accumulates and leaks. B. Lysosomal enzymes lack oligosaccharides. C. Lysosomal enzymes are secreted by accident. D. The mannose-6-phosphate receptor is defective. E. All of the above
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Inclusion-cell (I-cell) disease In patients with I-cell disease, fibroblasts do not digest material in their lysosomes, undigested material accumulates as inclusions . The lysosomal enzymes are found in the patients blood.
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