462a_final_studyguide_2013

E if polar or nonpolar likely location is surface or

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Unformatted text preview: ct. Know relative locations of different types of amino acids in protein structures and how it relates to amphipathic secondary structures (i.e. if polar or nonpolar, likely location is surface or buried). Know the functional groups of each amino acid and ionization states. Understand how pKa values affect each amino acid and how pI for peptide can be estimated. Understand Ramachandran plots. Understand hydrogen bonding patterns within secondary structures. Identify sequences likely to form amphipathic α ­helices or β ­strands. Identify quaternary structures and their level of symmetry. Know the meaning of paralogs, orthologs and homologs and how to establish that two proteins are homologs. Understand the difference between convergent and divergent evolution. Know the major techniques used in protein purification and the basic principles by which they work. Be able...
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