462a_prac_prob_7_2013_key

Draw this substrate then roughly diagram the oxyanion

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Unformatted text preview: problems 11/10/13 p. 2 4. Elastase will cleave a single peptide bond in a peptide substrate with the sequence RAEF. Draw this substrate, then roughly diagram the oxyanion hole and a specificity pocket around the appropriate groups on the substrate, and identify the scissile peptide bond in the substrate. oxyanion hole O H 3N CH C O H N CH2 CH O H N C CH 3 scissile peptide bond specificity pocket NH C H N C CH CH2 CH2 CH2 CH O C O CH2 CH2 C O O NH 2 NH 2 5. Draw the structures of both products of the cleavage of RAEF by elastase, and identify which one would be released in the burst phase of a transient kinetic...
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