Biological process is phdependent arrangement of

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Unformatted text preview: aragine Glutamic Acid Glutamine Lysine 3 leDer Cys His Ile Met Ser Val Ala Gly Leu Pro Thr Arg Phe Tyr Trp Asp Asn Glu Gln Lys 1 leDer C H I M S V A G L P T R F Y W D N E Q K explana+on First leaer of the name First leaer of the name First leaer of the name First leaer of the name First leaer of the name First leaer of the name First leaer of the name First leaer of the name First leaer of the name First leaer of the name First leaer of the name aRginine Fenylalanine tYrosine tWiptophan (or, contains Double ring) asparDic Contains N (or asparagiN) gluE (or glutamEke) Q ­tamine K is near L in the alphabet pH is controlled pH = " log[H + ] ! •  Biological process is pH ­dependent •  Arrangement of protons is essenGal for enzyme acGvity IonizaGon properGes of amino acids/zwiaerions Carboxyl group pKa ≈ 2 ­3 Amino group pKa ≈ 8 ­9 (dipolar ions) At physiological pH (≈7), the amino groups are protonated and the carboxylic acid groups are in their conjugate base (carboxylate) form The pKas of α ­amino and α ­carboxyl groups are slightly different depending...
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This test prep was uploaded on 02/25/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Spring '08 term at University of Arizona- Tucson.

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