L07_peptides_2013_462a

Stable structure that determines a par1cular func1on

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Unformatted text preview: e and sequence –  Cri1cal regions that are essen1al to their func1on are conserved (bioinforma1cs) Example  ­ Insulin •  Two polypep1de chains – cross ­linked by disulfide bond •  Human and dog have iden1cal chain A •  but not B Lengths/sizes of proteins •  Most polypep1des are between 100 and 1000 residues in general •  Minimum of ~40 or 50 residues for a protein chain to fold into a stable structure that determines a par1cular func1on •  Very large proteins (many 100s of residues) have a higher chance of transcrip1on error, and can be difficult to fold into a correct structure •  A protein can be composed of mul1ple polypep1de chains (mul1 ­subunit proteins) Distribu1on of yeast proteins by # of proteins vs. size Distribu1on of yeast proteins By abundance vs. Size Warrringer & Blomburg (2006) BMC Evol Biol 6:61 (Da) Molecular weight ≈ 110 daltons/residue hap://www.rcsb.org/pdb/sta1c.do?p=educa1on_discussion/edu...
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