Be able to identify helices and strands or sheets

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Unformatted text preview: conformation. •  Explain what a β-turn is, where β-turns are often found in proteins, and what types of amino acid residues are often found in β-turns. •  Be able to identify α-helices and β-strands (or β-sheets, which consist of 2 or more β-strands) on a ribbon depiction of a protein structure. •  Be able to identify α-helices and β-strands/sheets in a Ramachandran diagram Overview of Protein Structure 1.  The three ­dimensional structure of a protein is determined by its amino acid sequence. 2.  Protein funcCon depends on protein structure. 3.  Non ­covalent interacCons are the major forces stabilizing protein structure. 4.  Proteins exist in one or a small number of stable states. 5.  Protein structure is dynamic – proteins can “breathe” and “flex” Levels of protein structure Sequence (order) of amino acids in chain (synthesized in the order specified by the sequence of nucleo:des in a gene) Amino acid residues are linked by pepCde bonds 0) Structure Primary (1 •  The amino acid sequence of the protein and locaCons of any disulfide bonds in the sequence. •  N→C : Goes from N terminus to C terminus •  Every protein has a unique amino acid sequence that encodes its structure and funcCon •  1° structure is stabilized/held together by covalent bonds (pepCde bonds) •  Example:  ­Lys ­Lys ­Gly ­Gly ­Leu ­...
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This test prep was uploaded on 02/25/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Spring '08 term at University of Arizona- Tucson.

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