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Unformatted text preview: DEamino acid
equivalent CONFIGURATIONS OF the side chain R). An CHAIN
residue (other than glycine) has no B. COREY, elements. BRANSON* operBy LINUS PAULING, ROBERT symmetry AND H. R. The general
of CRELLIN LABORATORIES chain into
ation of conversion ANDone residue of a singleOF CHEMISTRY,a second residue
equivalent to the first is accordingly a rotation aboutCALIFORNIAt
CALIFORNIA INSTITUTE OF TECHNOLOGY, PASADENA, an axis accompanied
by translation along the axis. Hence the only configurations for a chain
postulate of equivalence of
compatible with our Communicated February 28, 1951 the residues are helical
configurations. For rotational angle 1800 the helical the problem of the
During the past fifteen years we have been attacking configurations may
degenerate to a simple chain ways. of of principal atoms, complete
structure of proteins in several with all Onethe these ways is the C, C' (the
carbonyl carbon), N, and 0, in
and accurate determination of the same plane.
crystal structure of amino acids, pepWe assume simple substances resonance of the in order that infortides, and otherthat, because of therelated to proteins,double bond between
mation about interatomic distances, bondpositions, the configuration of each
the carbon-oxygen and carbon-nitrogen angles, and other configurational
parameters might be obtained that would permit the reliable prediction of
residue >N-C6 is used
reasonable configurations for the polypeptide chain. We have nowplanar.
this information to construct two reasonable hydrogen-bonded helical conThis structural likely has been
figurations for the polypeptide chain; wte think that it is featurethat these
verified for each of the amides that
configurations constitute an important part of the structure of both f...
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This test prep was uploaded on 02/25/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Spring '08 term at University of Arizona- Tucson.
- Spring '08