Residues are packed beer in protein than with water

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Unformatted text preview: ac/ons contribute li^le? H ­bonds •  all poten/al donors and acceptors will form H ­bonds in the na/ve or denatured states •  denatured state – with water •  na/ve state – specific H ­bonds e.g. α ­helices and β ­sheets Ionic interac)ons •  forma/on of salt bridges within the protein involves desolva/on of the ion (unfavorable) followed by electrosta/c interac/ons between oppositely charged ions within the protein (favorable) Result: net enthalpy difference from H ­bonds and ionic interac/ons is small, but the forma/on o...
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