Mutaons that cause aggregaon 2 mutaons that lead to

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Unformatted text preview: What’s the mechanism? γ1 subunit Ser143 Adult: His143 Fetal: Ser143 Ser143 γ2 subunit Mutant hemoglobins: Learning about proteins from experiments of nature •  •  •  •  •  Mutant hemoglobins: unique opportuni.es to explore structure ­func.on rela.onships in a protein Hundreds of mutant Hb’s described, mostly single AA subs.tu.ons ~5 ­7% of humans carry variant hemoglobins, many of which are “silent” phenotypically (no symptoms) But some cause serious diseases  ­ ­ structure so delicately balanced that some small changes can seriously affect func.on Five kinds of Hb muta:ons we’ll consider: 1.  muta.ons that cause aggrega.on 2.  muta.ons that lead to loss of heme 3.  muta.ons that disrupt ter.ary structure of a subunit 4.  muta.ons that stabilize methemoglobin 5.  muta.ons that alter stability of R state or T state 1. Aggrega:on: sickle cell hemoglobin (HbS) βE6V (change of normal β...
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This test prep was uploaded on 02/25/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Spring '08 term at University of Arizona- Tucson.

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