L33_nucleicacids1_462a_2013

One can speak of the 5 end or 3 end of a strand is

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Unformatted text preview: 3 4 5 2 6 1 5’ 1’ 4’ 3’ Symbols: C, CMP 2’ β-1'-Nglycosidic bond Linkage of sugar to phosphate Ribonucleotides (5' monophosphate forms) diphosphate forms: ADP, GDP, UDP, CDP triphosphate forms: ATP, GTP, UTP, CTP Nucleic acids (DNA/RNA) are polymers of nucleotides a phosphodiester links the 3' hydroxyl of one nucleotide sugar to the 5' hydroxyl of the next the 5'-3' linkage gives RNA and DNA strands a polarity or directionality. One can speak of the 5' end or 3' end of a strand. Is this DNA or RNA? Primary structure of RNA and DNA strands Primary structure: sequence of nucleotides covalently linked into a polymer (specified in 5’ to 3’ direction) Each strand has polarity (directionality) of the sugarphosphate backbone. The ends of the strands have a 5’ phosphate group and a 3’ hydroxyl group What is the primary structure of each of these two strands? Phosphate Group NucleoLdes = strong acids Two phosphate pKa’s of phosphomonoesters: pK1 = 0.7 ­1.0...
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