Bacterial cell wall polysaccharides are linked by

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Unformatted text preview:   InformaHon rich recogniHon molecules •  Glycolipids –  Membrane lipids with hydrophilic oligosaccharide head groups – also recognized by specific proteins. Bacterial cell wall polysaccharides are linked by peptides = Peptidoglycan Picture of lysozyme cleavage of glycosidic linkage: h]p://www.biochem.arizona.edu/classes/bioc462/462a/jmol/lysozyme/lys1.htm Bacterial cell walls contain heteropolysaccharides of alternating modified glucose units N-acetylglucosamine (GlcNAc or NAG) These two alternate and are joined by β14 glycosidic linkages— Try drawing this! N-acetylmuramic acid (Mur2Ac or NAM) (lactate) Lysozyme common in tears and bacterial viruses Picture of lysozyme cleavage of glycosidic linkage: h]p://www.biochem.arizona.edu/classes/bioc462/462a/jmol/lysozyme/lys1.htm Penicillin – a β-lactam antibiotic Blocks cell wall formation in bacteria by blocking action of the transpeptidases that form the pentaglycine crosslinks in the peptidoglycan structur...
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