Extracellular matrix extracellular matrix composihon

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Unformatted text preview: long!), chondroitin sulfate, keratan sulfate, heparin Function: components of the extracellular matrix, a porous gel between cells containing fibrous proteins (collagen, elastin, fibronectin). Shorter chains can be covalently linked to proteins in proteoglycans. Extracellular matrix Extracellular matrix: ComposiHon: A meshwork of glycosaminoglycans and proteoglycans that is embedded with fibrous proteins. Forms for example: CarHlage: Proteoglycans for flexibility Collagen for tensile strength Intercellular layer: Proteoglycans bind and organize extracellular receptors, direct cell and neuronal migraHon. Glycoproteins •  Glycoproteins: Proteins with one or more complex oligosaccharides – informaHon rich recogniHon molecules •  Sugar link to protein: O ­linked or N ­linked The sugar code: carbohydrates as informaHon •  20 monosaccharides, mulHple points for linkage (1→2),(1→3) (1→4), etc., linear and branching •  1.44 x 1015 possible hexameric oligosaccharides! –  only 6.4 x 107 hexapepHdes; 4,096 hexanucleoHdes Jmol of a glycoprotein: h]p://www.biochem.arizona.edu/classes/bioc462/462a/jmol/glycopro/glycopro1.htm Glycoprotein FuncHons •  The carbohydrate part of glycoproteins can: –  –  –  –  Mediate r...
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