L34_nucleicacids2_462a_2013

5 rise per bp 34 base mlt to axis 6o sugar pucker c2

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Unformatted text preview: equence DNA under physiological condiMons  ­ Right ­handed, double helix  ­ Major groove is wide and deep; minor groove is narrow and deep.  ­  Core of helix is Mghtly packed (no hole)  ­ Diameter ~ 20 Ǻ  ­ Bases pairs/turn 10.5  ­ Rise per bp 3.4 Ǻ  ­ Base Mlt to axis 6o  ­ Sugar pucker C ­2’ endo  ­ Glycosyl bond an0 http://www.biochem.arizona.edu/classes/bioc462/462a/jmol/bdna/bdna1.htm Relationship of the Major and Minor Grooves to the Base Pairs Can you identify the major and minor grooves for the base pairs above? A-DNA structure Favored under physiological conditions for RNA-RNA or RNA-DNA duplexes, because the 2’-OH of ribose sterically inhibits B conformation http://www.biochem.arizona.edu/classes/bioc462/462a/jmol/adna/adna1.ht...
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This test prep was uploaded on 02/25/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Spring '08 term at University of Arizona- Tucson.

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