L36L37_lipidmem_462A_2013sm

Nonpolar tails polar charged head johann ludwig

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Unformatted text preview: es you can make many different lipids by –  Changing the polar head group –  Changing the faXy acid •  Each change will alter the chemistry of the lipid while the amphipathic nature remains intact Glycerophospholipids Glycerol (a.k.a. phosphoglycerides) •  Glycerol has 3 alcohol groups •  Two are covalently aXached to faXy acids, the third to phosphoric acid •  The esterified faXy acids can be the same or different •  Other groups can be aXached to the phosphate group Nonpolar “tails” Polar charged “head” Some common glycerophospholipids acyl group with faCy acid glycerol phosphate alcohol Phospholipids: Sphingolipids (sphingophospholipids) amino group of sphingosine faXy acid primary hydroxyl amide bond to a faXy acid primary hydroxyl is esterified to phosphoryl choline or phosphoryl ethanolamine. Nonpolar “tails” Polar charged “head” Johann Ludwig Wilhelm Thudichum 1829 – 1901 Phospholipids: Sphingolipids (sphingophospholipids) amino group of sphingosine faXy acid primary hydroxyl amide bond to a faXy acid primary hydroxyl is esterified to phosphoryl choline or phosphoryl ethanolamine. Nonpolar “tails” Polar charged “head” Glycolipids: Sphingolipids amide bond to a faXy acid •  Sphingosine backbone •  The primary hydroxyl is esterified to one or more sugars •  Glycolipids are found on the exterior layer of the plasma membrane with the sugars outside the cell. Nonpolar “tails” Polar “head” Phospholipids (charged head group) Glycolipids (polar uncharged head group) Glycerophospholipids (glycerol backbone) Sphingophospholipids (sphingosine backbone) Sphingosine backbone Examples: PhosphaFdyl choline PhosphaFdyl serine Examples: Sphingomyelins Examples: Cerebrosides Gangliosides Each change will alter the chemistry of...
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