Binding to the cytoplasmic surface of an integral

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Unformatted text preview: here. Membrane proteins must sa:sfy their own hydrogen ­bonding groups. Membrane Three classes: embrane proteins 1.  integral m proteins 2.   lipid ­anchored proteins roteins 3. peripheral membrane p Peripheral membrane proteins •  Binds to (not covalent bond) integral membrane proteins and someEmes interact with polar head groups •  Weaker and temporarily a_ached Binding to extra ­cellular surface of protein and interacEon with polar head groups. Binding to the cytoplasmic surface of an integral membrane protein Lipid anchored protein: anchored to the membrane by covalently a_ached lipid anchors protein Lipid anchor protein Lipid anchor protein Soluble protein Lipid anchor Membrane anchor Transmembrane α ­Helices rise of 1.5 Å /residue Transmembrane helix Whole Bilayer ≈40 Å ≈27 residues ≈ 7 ­8 turns Hydrocarbon Core ≈30 Å ≈20 residues ≈5 ­6 turns •  Transmembrane α ­helices are comprised primarily of hydrophobic residues. Membrane spanning α ­helices •  The most common domains in integral membrane proteins •  The orientaWon of transmembrane helices must be carefully controlled for proper funcEon. •  The orientaEon of the different transmemb...
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