Phenotypically male due to male genitalia 19 eg x

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Unformatted text preview: notypically male due to male genitalia. 19 e.g. X chromosome Fertilization X XXX Turner Normal (2n) XXX 20 Turner e.g. X chromosome Y Fertilization XXY XXY OY OY XY XXY OY XY 21 Can Klinefelter’s be due to non-disjunction during meiosis in the male? a)  No b)  Yes, 1st division only c)  Yes, 1st or second division d)  Yes, 2nd division only 22 e.g. in male Y X X Fertilization XXY XXY XO XO XY XY XXX XO 23 male calico cat - kleinfelters, XXY not humans monosomic don’t survive. (or mammals) Consequences of aneuploidy 24 Trisomy 21 - theoretically - 50% normal gametes - reality: trisome 21 males are always infertile. females have low fertility Aneuploid mosaics can result from mitotic nondisjunction or chromosome loss -occurs early in embryo development after fertilization (e.g., during the first mitotic division) some cells are normal diploi, some are monosomic. 25 Clones of aneuploid...
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This document was uploaded on 02/25/2014.

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