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Unformatted text preview: notypically male due to male genitalia. 19 e.g. X chromosome Fertilization
XXX Turner Normal (2n) XXX 20
Turner e.g. X chromosome Y Fertilization
XXY XXY OY OY XY XXY OY XY 21 Can Klinefelter’s be due to
non-disjunction during meiosis in
b) Yes, 1st division only
c) Yes, 1st or second division
d) Yes, 2nd division only 22 e.g. in male Y X X Fertilization
XXY XXY XO XO XY XY XXX XO 23
male calico cat - kleinfelters, XXY not humans monosomic don’t
(or mammals) Consequences of aneuploidy 24 Trisomy 21 - theoretically - 50% normal gametes
- reality: trisome 21 males are always infertile. females have low fertility Aneuploid mosaics can result from
mitotic nondisjunction or chromosome
-occurs early in embryo development
after fertilization (e.g., during the first mitotic
some cells are normal diploi, some are monosomic. 25 Clones of aneuploid...
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This document was uploaded on 02/25/2014.
- Winter '14