A functional polymorphism in the hfe gene and risk

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Unformatted text preview: w Activity Atypical Risk Typical Activity High Activity Example: A Functional Polymorphism In The HFE Gene And Risk For Hemochromatosis Genetic Factors Interact With Nongenetic Factors Nongenetic Factors Genetic Factors Genetic And Nongenetic Factors May Interact In Several Different Ways Two factors may add together Two factors may counterbalance each other Two factors may multiply each other Two factors may interact synergistically Whether A Gene Allele Is Risk-Increasing Or Risk-Decreasing Depends On Two Factors Some proteins create disease-causing agents Ex: enzymes that metabolize fat create superoxide radicals, which can cause atherosclerosis (hardening of the arteries) Some proteins protect you against disease-causing agents Ex: proteins that repair DNA damage after sun exposure Protein Prevents Or Protein Creates The Repairs Damage Disease-Causing Done By DiseaseAgent Causing Agents High-Activity Version Risk-Increasing Allele Low-Activity Version Risk-Reducing Allele Risk-Reducing Allele Risk-Increasing Allele Even If You Have A Heavy Genetic Load, You May Still Be Able To Treat The Disease You can control your diet, environment and lifestyle to severely reduce your exposure to the nongenetic factors that increase your risk for the disease You can get screening tests earlier and more often than is recommended for most people This may enable the disease to be detected early, when it can be successfully treated Using Genetics To Personalize Medicine Genetic tests can tell you: Which diseases you have the greatest level of risk for Which of several treatments/drugs is likely to be the safest and most effective treatment for you Whether you get a high, medium or low dose of a drug What sort of adjustments you can make in your diet, environment and lifestyle to reduce your overall risk of developing the diseases for which you have the greatest level of genetic risk One Test Would Increase Safety And Effectiveness For Many Drugs One test focuses on three members of the big family of cytochrome oxidase genes/proteins (all names begin with “CYP”)—CYP2D6, CYP2C19, CYP2C9 These three enzymes help metabolize 30-40% of our prescription drugs Some people have duplications in their DNA that give them up to 13 copies of the CYP2D6 gene Many of these people are ultrafast metabolizers—they need to be given a high dose of the drug, because they clear the drug out of their body faster than most people do One Test Would Increase Safety And Effective...
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This document was uploaded on 02/25/2014.

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