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You could have risk decreasing alleles in other genes

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Unformatted text preview: overall risk for the disease could be low, even if you have a risk-increasing allele. You could have risk-decreasing alleles in other genes, or you may not be exposed to a critical nongenetic factor. It Is Important To Know The Penetrance Of A Risk-Increasing Allele Because of the high number of gene variants that can influence your risk for a disease, it is easy to imagine that you could have one risk-increasing gene allele but not get the disease Penetrance = the percentage of people who have the risk-increasing allele and also develop the disease Very few risk-increasing gene alleles have been discovered that have high enough penetrance by themselves to significantly influence your risk for a specific disease or cause you to undergo aggressive medical screenings or treatments; in fact, most penetrances are very low It Is Important To Know The Penetrance Of A RiskIncreasing Allele The FDA Will Soon Begin Regulating Direct-To-Consumer Testing Recently one of the genetic testing companies (Pathway Genomics) signed an agreement with one of the well-known pharmacies (Walgreens) to put genetic testing kits on drug store shelves The FDA blocked this, because this unregulated process results in the consumer getting the information without having someone there who can clearly explain what it does and does not mean for their future health prospects The reports all provide a phone number or website where you can contact a genetic counselor who can help you understand the meaning and significance of the test results, but the FDA (correctly) foresees a lot of people suffering a great deal of (often unnecessary) anxiety between the time they read the report and the time they talk to the counselor One Final Example G Allele GENE 1 Glycine version of protein Average level of activity C Allele Alanine version of protein 20% less activity G Allele Glycine version of protein Average level of activity GENE 2 A Allele Aspartic acid version of protein 80% less activity Gene 1 Gene 2 GC GA GC GA Sam Gene 1 Gene 2 Gene 1 Gene 2 Marcie GG GG GG AG CG AG CC AA Kaitlyn Dianne Kent Douglas Kaitlyn Average Risk Dianne Slight Increase Kent Moderate Increase Douglas Significant Increase Gene 1 Gene 2...
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This document was uploaded on 02/25/2014.

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