Testing they use devices called microarrays to test

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Unformatted text preview: e their services directly to consumers (referred to as DTC testing) They use devices called microarrays to test hundreds of thousands of polymorphisms in your DNA They provide information about physical traits, personality traits, ancestry Ethical Objections To Direct-To-Consumer Testing Regulatory agencies such as the Food and Drug Administration, which also approves medical devices, worry about lay people receiving information they cannot interpret properly Ordinarily you must go see a doctor to get any medical information, so you have someone right there to explain the results and what they mean Genetic counselors help people choose which genetic tests to have, and help them interpret the information Interpreting The Results Of The Test May Be Very Complicated THE TESTS ARE INCOMPLETE They do not include all the genes you need to know about in order to capture all the genetic factors that influence any one trait Your genetic test may tell you that you have an increased risk for something, but you may never get it, because you don’t have the other necessary genetic/nongenetic factors Your genetic test may tell you that you have a decreased risk for a trait you already have—you have other genetic or nongenetic risk factors It Can Be Hard To Know The Effect A Sequence Variant Will Have On The Protein’s Activity If an amino acid substitution involves two amino acids that are moderately different in size or charge, it may be hard to know if this changes activity For many genes, we still do not know what sequences serve as the promoter/regulatory sequences Common Wordings Can Cause Anxiety And Confusion The situation isn’t helped by the fact that many of these reports call these risk-increasing and risk-decreasing alleles “high risk” and “low risk” alleles Most gene polymorphisms only affect your risk for diseases by a little bit, so someone can easily misinterpret the report that says “you have a highrisk allele” as saying “you have a high risk for the disease” In fact, your...
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This document was uploaded on 02/25/2014.

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