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To 100 sequence changes that are thought to be

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Unformatted text preview: quence Abnormalities The typical person has approximately 50 to 100 sequence changes that are thought to be capable of causing a genetic disease if both copies of the gene had that sequence (i.e. recessive disease-causing mutations). With a recessive gene mutation, if you only have one mutant copy of the gene, the normal copy dominates over the mutant copy, and you will not be affected with the disorder This means unless you actually test someone, you cannot tell if he/she is a carrier of the mutation—it is easy to partner up with someone who is a carrier and not know it Healthy People Have Potentially Disease-Causing Sequence Abnormalities When parents pass their DNA down to their children, it is typical for approximately 30-35 single base changes to occur in the DNA sequence as it is passed from the parent to the child. These are called “de novo” mutations, because they have arisen anew in that individual The Activity Level Of A Protein Is Normally Distributed In A Large Population Most people have close to the typical level of activity But there are always a few who have extreme values Multifactorial Disorders Are Caused By A Combination Of Genetic And Nongenetic Factors As the name implies, multifactorial disorders have multiple causes Caused by a combination of genetic factors and nongenetic factors Genetic factors refers to the fact that there are many different versions of a typical gene’s sequence in the population (i.e. many different alleles of that gene) Different alleles of the gene make different forms of the protein that have different levels of activity Nongenetic factors refers to the disease-causing agents you expose yourself to through your diet, environment and lifestyle Multifactorial Disorders Are Far More Common Than Single-Gene Disorders, And Represent A Greater Total Burden On Human Health Multifactorial disorders affect far more people than single-gene disorders do Multifactorial disorders are more common in older people, and often worsen as you age Multifactorial disorders significantly compromise health for a large portion of your life Multifactorial Disorders Include Cancer Cardiovascular disease Substance Abuse Diabetes Respiratory Disorders Psychiatric Disorders Age-Related Cognitive Decline And Many More Common Conditions That Touch So Many Lives “Genetic Factors” Refers To The Specific Alleles You Possess For Critical Genes And The Level Of Activity You Have In Those Proteins Typical Risk Atypical Risk Lo...
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This document was uploaded on 02/25/2014.

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