F13 lecture 5 - Single locus gene,c varia,on at equilibrium...

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Single’locus’gene,c’varia,on’at’ equilibrium’ the’Hardy-Weinberg’Principle’
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a’model’of’gene,c’varia,on’at’one’ locus’ simplest’and’most’common:’two’alleles’ but’mul,ple’alleles’can’be’modeled’ a’model’is’a’mathema,cal’simpliFca,on’ dis,lls’a’phenomenon’to’its’essence’ used’to’make’predic,ons’about’nature’ the’H-W’model’is’a’very’useful’null’hypothesis’ we’discussed’null’hypotheses’earlier’ Mendelian’segrega,on’ra,os’
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Hardy-Weinberg’Principle’ frst’popula,on’theory’that’involved’the’newly’ rediscovered’Mendelian’gene,c’principles’ independently’discovered’and’published’in’the’same’year’ (1908)’ Weinberg’was’not’credited’For’this’un,l’35’years’later’–’ probably’because’he’published’in’German’and’most’ gene,cists’oF’that’era’published’in’English’ G. H. Hardy (1877-1947) [Matheme±cian] W. Weinberg (1862-1937) [Physician, Gene±cist]
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H-W models a popula7on with the following characteris7cs
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F13 lecture 5 - Single locus gene,c varia,on at equilibrium...

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