F13 lecture 10

G aa10 replacing an a with an a adds or substracts a

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Unformatted text preview: subpopula7on is rare different effects of true inbreeding and gene?c driF •  true inbreeding – reduces frequency of heterozygotes and increases frequency of both homozygotes •  driF – reduces frequency of heterozygotes and increases the frequency of only one homozygote within each subpopula7on different effects of true inbreeding and gene?c driF •  => small pop size does not increase FIS but does increase FST –  with gene7c dri_ and random ma7ng, actual H within subpopula7ons always equals expected H (HI = HS) [but both decline] •  FIS = 0 ; FST increases effects on phenotype •  generally similar between gene7c dri_ and inbreeding •  non- adap?ve change in phenotype –  deleterious alleles can dri_ to high frequencies –  become commonly expressed (lots of homozygotes; even at HWE) example from the book IV •  Templeton and Read (1994) –  cap7ve breeding program for Speke’s gazelles, an endangered species –  pop founded by one male and three females •  extreme founder event •  Ne = 3 =>Ne = 4(NmNf)/(Nm+Nf) –  only 8 alleles for each locus in this pop –  ini7al freq....
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This document was uploaded on 02/27/2014.

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