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F1 females b c d e a b c d e a x

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Unformatted text preview: Neo- Darwinian “many genes of small effect”, implying gradual evolu/on vs. Goldschmid/an/Punctuated Equilibrium view of “single genes of large effect”, which implies rapid, salta/onal evolu/on •  It is important to know what the genes are –  To look for varia/on within popula/ons/species and study its history and the forces behind it –  To understand how different kinds of genes (transcrip/onal regulators, signaling proteins, enzymes, etc.) are involved in phenotypic evolu/on Quan*ta*ve trait locus (QTL) mapping •  Genome- wide test of associa/on between gene/c markers and a phenotypic difference between two strains or species •  Usually performed on backcross or F2 popula/ons from a cross between two divergent strains or species •  Detects: –  Approximate # of contribu/ng loci (QTL) –  Magnitudes of effect of each QTL •  Limita/ons –  # loci detectable is limited by number of markers –  Loci of very small effect oken go undetected F2 progeny analysis Parental line 1 low trait value females a b c Parental line 2: high trait valu...
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