Oxidative phosphorylation HO

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Unformatted text preview: uch be fatal? Other inhibitors Many poisons act by inhibiBng oxidaBve phosphorylaBon: •  InhibiBon of the electron transport chain •  InhibiBon of ATP synthase •  InhibiBon of ATP ­ADP translocase Images: http://www.flickr.com/photos/32912641 and http://www.bitesmosquito.com/ 9 1/04/11 Uncoupling generates heat Some organisms use uncoupling to generate heat. •  Non ­shivering thermogenesis in the brown adipose Bssue of animals. •  Thermogenin / UCP ­1 in the mitochondrial inner membrane allows protons to flow to the matrix. •  The energy of the proton gradient is released as heat rather than captured as ATP. Images: http://carolynsshadegardens.com/2011/02/09/are-snowdrops-thermogenic/ http://www.bbc.co.uk/nature/adaptations/Hibernation Reac&ve Oxygen Species The reducBon of O2 to H2O by Complex IV requires four elecBons. Occasionally, O2 is only parBally reduced, creaBng reacBve oxygen species (ROS). The best known ROS is the superoxide radical:  ­ O2 + e ­ → O2  10 1/04/11 Reac&ve Oxygen Species  ­ The half life of O2  is 1 x 10 ­6 s. Free radicals are short ­lived, but extract electrons from other molecules, converBng them to free radicals and thereby sehng off a chain reacBon. All classes of biological molecules are suscepBble to oxidaBve damage caused by free radicals. Effects include disrupBon of membra...
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This document was uploaded on 02/27/2014 for the course BIOC 2201 at University of New South Wales.

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