Oxidative phosphorylation HO

The chemiosmoc theory some compounds increase the

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Unformatted text preview: smo&c theory The inner mitochondrial membrane is impermeable to ions such as H+, OH ­, K+ and Cl ­. What would occur if these could diffuse freely? The chemiosmo&c theory Some compounds increase the permeability of the inner mitochondrial membrane to H+. This dissipates the electrochemical gradient . When this occurs, electron transport can conBnue, but ATP synthesis cannot occur. What would happen if the environment outside the inner mitochondrial membrane became acidic? 4 1/04/11 ATP Synthase aka. F1F0 ­ATPase A mulB ­subunit protein protein comprising two funcBon units, F1F0. F1 a water ­soluble peripheral membrane protein. F0 a water ­insoluble transmembrane protein. An electron micrograph of cristae from mitochondria show F1 lollipops projecBng into the matrix. ATP Synthase LHS: Electron micrograph showing F1 and F0 are connected by a central stalk and, to a lesser extent, are also connected peripherally. Cytoplasm RHS: Model of E. coli F1F0 ­ATPase. ϒε ­c12 is a rotor. ab2 ­α3β3δ is staBonary. b2δ appears to prevent the stator from moving. Trace the movement of the H+… Periplasmic space 5 1/04/11 ATP Synthase Change binding mechanism: The influx of H+ through F0 drives F1 to synthesise ATP from ADP + Pi via the binding change mechanism, powered by the rotaBon of F1 s ϒ subunit with respect to α3β3. The P/O ra&o Since ATP synthesis is Bghtly coupled to the proton gradient, and the proton gradient is established via the electron transport...
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