Enzyme halorhodopsin discovered in 1973 retinol

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Unformatted text preview: binding pocket Light- driven proton pump (outward) Light- driven anion pump (inward) Halobacterium salinarum growing around/on salt crystals on a dried- out plate. 7 β-Carotene + O2 Some properties of light-driven ion pumps Enzyme Bacteriorhodopsin + Retinal (chromophore) Discovered in 1980 A single- site mutaCon in bacteriorhodopsin converts it from a proton pump to a Cl– pump. Enzyme Halorhodopsin Discovered in 1973 Retinol (Vitamin A) – H2 Opsin (protein) 8 Share sequence idenCCes (25–35%) with bacteriorhodopsins ReCnal- containing protein Integral membrane proteins with seven alpha helices across the cytoplasmic membrane, surrounding the re3nal- binding pocket Light- driven proton pump (outward) Bacteriorhodopsin (Rhodopsin) Light- driven anion pump (inward) 9 10 Bacteriorhodopsin and Halorhodopsin Some properties of light-driven io...
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This document was uploaded on 02/27/2014 for the course BIOC 2201 at University of New South Wales.

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