{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

when activated the protein kinase phosphorylates

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: cells. In glucose ­dependent /ssues, glucose transport is NOT insulin dependent. • It func;ons to promote growth and fuel storage a`er a meal. • It s;mulates glycogen synthesis, faZy acid synthesis, amino acid uptake and protein synthesis. 2 20/05/13 Receptor Tyrosine Kinases These receptors have a protein kinase enzyme activity associated with the cytoplasmic domains, and an extracellular ligand-binding (hormone-binding) domain." " When activated, the protein kinase phosphorylates itself and then particular amino acid side chains (normally tyrosines) in susceptible cytoplasmic proteins, initiating a response." " The activated receptors are always dimers with a single transmembrane domain in each subunit, but vary in other structural properties. " The Activated Receptors are Dimers Intracellular domains have tyrosine kinase activity and cross phosphorylate each other (Tyr --> Tyr-P), activating the receptor and initiating further signalling. Some recept...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online