BIOC2101 Hormonal Control(1)

2 glucagon is secreted by cells in response to low

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Unformatted text preview: cation c p e p tid e b o n d s , e .g . in p r o te in d ig e s tio n a n d Control of Intracellular Enzymes via Phosphorylation Glucagon P h o s p h o r y la tio n a n d d e p h o s p h o r y la tio n o f h y d r o x y l ( - O H ) g r o u p s o n a m in o a c id s id e c h a in s is a c o m m o n m e c h a n is m fo r c o n tr o llin g e n z y m e a c tiv ity ( a n d th e fu n c tio n s o f o th e r p r o te in s s u c h a s r e c e p to r s a n d tr a n s p o r te r s ) . FASTED w ith a p a r tic u la r a m in o p h o s p h o r y la tio n a n d Activity (function) can be switched “on” or “off” in d iffe r e n t p r o te in s b y p h o s p h o r y la tio n . 2 •  Glucagon is secreted by α cells in response to low blood glucose levels. •  Secre;on inhibited by glucose and insulin, and s;mulated by amino acids. •  Func;ons to mobilise fuels for maintenance of blood glucose levels during fas;ng. •  It s;mulates glycogen breakdown and gluconeogenesis...
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