BIOC2101 Hormonal Control(1)

Tyrosine residues on the subunits are

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Unformatted text preview: ors (e.g. for growth hormone and EGF) only dimerise when the hormone ligand is bound." Insulin Receptor This receptor tyrosine kinase is a dimer even in the absence of the ligand (insulin)." " In addition, each half of the dimer comprises an α- and β- subunit linked by a disulphide bond. In other tyrosine kinases each subunit is a single polypeptide chain. outside plasma membrane inside " Insulin receptor • Insulin binding ac;vates receptor tyrosine kinase ac;vity of the β ­subunit of the receptor. • Tyrosine residues on the β ­subunits are autophosphorylated. • Receptor tyrosine kinase phosphorylates other proteins (insulin ­receptor substrate ­1) . • Ac;va;on of other kinases and phosphatases leading to the biological ac;vity of insulin. Insulin receptor Akt 3 20/05/13 Effects of Insulin GLUT4 acFvity is regulated by insulin Insulin binding to the insulin receptor induces a signal LIVER Glycogen +  ­ transduc;on cascade which allows the GLUT4 func;on. Glucose SKELETAL MUSCLE Protein +  ­ + FaZy acids VLDL cellular Enzymes roperties in v a r ia b ly h a v e q u a te r n a r y e tw o o r m o r e s u b u n its in a c tiv e Protein CO2 + ADIPOSE TISSUE Image source: hZp://;cle_panel_images/...
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