BIOC2101 Hormonal Control(1)

Phosphofructokinase and inhibits gng g enzyme

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Unformatted text preview: insulin ­receptor ­GLUT4_w500.jpg A llo s te r ic e n z y m e s o s c illa te b e tw e e n a n a c tiv e a n d a n in a c tiv e c o n fo r m a tio n + FaZy acids  ­ + Triacylglycerols Allosteric Enzymes - mechanism a c tiv e n z y m e s th a t a r e im p o r ta n t ta b o lis m h a v e a llo s te r ic + Amino acids Glucose A llo s te r ic a c tiv a to r s a n d in h ib ito r s b in d r e v e r s ib ly a n d lo c k th e e n z y m e in th e a c tiv e o r in a c tiv e c o n fo r m a tio n In the liver… SUMMARY: FED •  Insulin increases [Fructose ­2,6 ­bisP] in the liver, which ac;vates glycolysis (via phosphofructokinase) and inhibits GNG g enzyme activity (fructose bisphosphatase). breakdown Control of glucose r e c ta n g u la r h y p e r b o la T h e e n z y m e a c tiv ity c a n b e a lte r e d o v e r a r a n g e o f ~ 2 0 fo ld b y th e a llo s te r ic a c tiv a to r . a llo s te r ic - “ S ” s h a p e d yme Activity modifi...
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