05 Mutations and DNA repair mechanism

Example cytosine to uracil intercalating agents

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Unformatted text preview: Example: Cytosine to Uracil INTERCALATING AGENTS -contains a cyclic system that can interact with the bases of DNA -do not chemically modify DNA but physically binds to it by becoming inserted between adjacent base pairs because of their flat ring structures. This affects the opening of the DNA during replication or transcription. Binary Fission Example: Benzopyrene (found in automotive exhaust and cigarette smoke), Benzene (an organic solvent), Aflatoxin (a metabolic product of molds in peanuts, oils and grains) VIRAL AGENTS -some viruses contain oncogenes (cancer-causing genes) which can be activated once they insert their DNA in the host’s genome (the process is called lysogeny). -the virus that infects a cell may either undergo lytic or lysogenic cycle -when viruses insert their DNAs into the host genome, the sequence of the bases of the host DNA may be altered or certain destructive genes can be activated. Isidro C. Medina Jr. Page 5 of 7 Mutation & DNA Repair Mechanism Isidro C. M...
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This document was uploaded on 02/27/2014.

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