Chapter 20 Study Questions--answers at end

Chapter 20 Study Questions--answers at end - CHAPTER 20...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
CHAPTER 20 STUDY QUESTIONS 1) What sets genomics apart from genetics? A. Genomics deals with DNA sequences; genetics never considers such sequences. B. A goal of genomics is to understand how genes influence phenotype; genetics never considers this question. C. Genomics is based almost solely on studies of humans; genetics is far broader in its reach. D. Genomics is based on DNA sequence analysis and considers the sequence, function and interactions of many genes; genetics more often considers one or a small number of genes at a time and is generally involved in the passage of hereditary traits from one generation to the next. E. Genomics deals with genomes; genetics deals with gene products. 2) Computer scientists are indispensable in genomics research because these individuals are behind: A. biological modeling B. artificial life theory C. DNA sequencing D. bioinformatics E. BAC development 3) Assuming an insert size of 160 kb, what is the minimum number of BAC clones required to cover the entire haploid human genome? A. about 10 B. about 200 C. about 800 D. about 1900 E. about 5400 4) BAC clones are constructed by cloning either restriction-enzyme digested or randomly fragmented DNA of the desired size range into BAC vectors. Assuming an average insert size of 160 kb, and knowing the way the DNA is fragmented, approximately what number of BAC clones would be required to have most human DNA sequences (say, 95%) present in the BAC library? A. about 10 B. about 200 C. about 800 D. about 1900 E. about 5400 5) Assume a sequencing facility can run 100,000 sequencing reactions per day, each providing a read length of 1,000 nucleotides. Assume further that the goal is to have sixfold redundancy of coverage (i.e., six times as much DNA is sequenced as there are base pairs in the genome). For the human haploid genome, how many days would be required to generate the sequence data? A. 3 days B. 18 days C. 28 days D. 64 days E. 180 days 6) What is the difference between an open reading frame (ORF) and a gene? A. There is no difference. B. An ORF is a potential gene identified by a potential protein-coding segment in DNA; a gene is a DNA segment known to produce a product. C. An ORF is a known protein-coding gene identified by computational means (by computer); a gene is segment of DNA that may encode either RNA or DNA and identified by noncomputational means. D. An ORF is a known gene-containing DNA segment that is shorter than a full-length gene. E. An ORF may or may not have introns; a gene must have introns. 7) cDNAs synthesized for use as probes of genes within a whole-genome sequence are known as expressed sequence tags or ESTs. Which functionally important features of the genome would ESTs not detect? A.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This test prep was uploaded on 04/08/2008 for the course BIOL 203 taught by Professor Saha during the Spring '08 term at William & Mary.

Page1 / 18

Chapter 20 Study Questions--answers at end - CHAPTER 20...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online