BCHE 395-6 2013 Protein Motifs and Sequencing

What is its three dimensional structure how does it nd

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Unformatted text preview: 10 Mo1fs and Structural Classifica1on –  Four classes: all α; all β; α/β; and α + β 11 Mo1fs and Structural Classifica1on –  Four classes: all α; all β; α/β; and α + β 12 Intrinsically Disordered Proteins •  Contain protein segments that lack definable structure •  Composed of amino acids whose higher concentra1on forces less- defined structure –  Lys, Arg, Glu, and Pro •  Disordered regions can conform to many different proteins, facilita1ng interac1on with numerous different partner proteins •  “Promiscuous” proteins” 13 What to Study about Pep1des and Proteins •  What is its sequence and composi@on? •  What is its three- dimensional structure? •  How does it find its na1ve fold? •  How does it achieve its biochemical role? •  How is its func1on regulated? •  H...
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