BCHE 395-9 2013 Ligand Binding and Hemoglobin

which then forms a salt bridge with asp94 leads to

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Unformatted text preview: during respiraNon [O2]ê༎: [CO2]é༎ Tiss ues 17 pH Effect on O2 Binding to Hemoglobin •  AcNvely metabolizing Nssues generate CO2 (gas) as a “waste” product of cellular respiraNon (Ch. 14- 16) –  CO2 not very soluble in aqueous soluNon –  CO2 bubbles would form in blood if stayed as gas (like decompression sickness or caisson disease) so… •  CO2 (80- 85%) is hydrated to form bicarbonate –  Enzyme: Carbonic anhydrase •  CO2 + H2O ß།à༎ H+ + HCO3- ß།à༎ H2CO3 •  (p. 66- 67) –  Major blood buffering system pH Effect on O2 Binding to Hemoglobin O H C + H2N−C−C− O R O Amino- Terminal residue H+ O− H H C−N−C−C− O R O Carbamino- Terminal residue •  CO2 (15- 20%) is bound to amino- terminal residues of the hemoglobin of each of the polypepNde subunits •  Exported to the lungs in the form of a carbamate •  FormaNon of a carbamate yields a proton which can contribute to the Bo...
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