BCHE 395-11 2013 Enzymes Intro

as opposed to chemical catalysts oen require a

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Unformatted text preview: alyst 3 Enzymes: Fun Facts •  Are (almost) always proteins (globular) •  Are extraordinarily efficient (103- 1012 bePer than chemical catalysts) •  Are remarkably specific (rarely result in side products like chemical catalysts) •  Need mild physiological condi8ons to funcKon (temperature, salt, pH, etc.) as opposed to chemical catalysts •  O:en require a cofactor (metal ion, prostheKc group, or coenzyme) •  May be modified for regulatory purposes Now wasn’t that fun? 4 EnzymaKc Substrate SelecKvity substrate product OH H - EnzymaKc rxn ✔ + NH3 OOC H OOC H - No binding + NH3 OOC + NH3 OH HO H H H NH OH Binding but no reacKon CH3 Example: Phenylalanine hydroxylase 5 Enzyme: Useful DefiniKons •  Substrate, S: molecules on which enzymes act to convert to product, P •  Cofactor: non- protein reagents that are essenKal parKcipants in enzyme- catalyzed reacKons –  Include metal ions, vitamins, coenzymes and prosthe8c groups (e.g. heme) –...
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