BCHE 395-11 2013 Enzymes Intro

Energe8c when compared to substrate and products can

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Unformatted text preview: 4 To make any sense of enzymes, you have to understand this page Enzymes: General FuncKon E + S ⇌ ES ⇌ EP ⇌ E + P •  Enzymes are biological catalysts that accelerate the rate of reac3ons 105- 1017 Kmes faster than the uncatalyzed reacKon –  (chemical catalyst are GREAT if increase rate 105) •  A catalyst does NOT affect the equilibrium constant OR the equilibrium state of a reac8on •  ONLY affects the rate with which a reacKon eventually ATTAINS equilibrium •  The catalyst is NOT changed in the overall process 15 Enzymes: General FuncKon •  Catalyst DO NOT change the equilibrium constant (K’eq) of a reacKon •  •  S ⇌ P K’eq = [P]/[S] •  •  K’eq stays the same in the presence and absence of the enzyme in the reacKon 16 Enzyme: Turnover Number E + S ⇌ E + P •  Mole of S (substrate) converted to P (product) per unit Kme per mole of enzyme •  Typically, the value is 100- 100,000 moles of S à༎ P min- 1/mole of enzyme •  Higher the number, more efficient the enzyme (cherry Turnover number: 3) 17 18 TransiKon State T...
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This note was uploaded on 03/02/2014 for the course BIOCHEMIST 395 taught by Professor Potenza during the Spring '14 term at NMSU.

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